Information on available vancomycin dosing calculators. Best viewed on desktop computer.

CalculatorDescriptorsOutput/MethodCostAccuracyEase of Use
Detroit Medical Center-Excel-based AUC platform developed and refined at DMC
-Editable patient specific factors and kinetics
-Limited access
Trough
AUC
Free-Bayesian methodology unavailable
-Multiple first-order equations available for use
-Provides graph of estimated levels for 48 hours
-Many editable fields of patient-specific and kinetic equations
-Clear input of and output of values/results
InsightRx-Cloud-based platform accessible via web or with integration into EHR
-Ability to save patient profiles-Multiple adaptable Bayesian models available
Trough
AUC
Bayesian
Fee-based-Iterative improvement based on input of levels
-Responsive to patient specific changes
-Requires input of doses administered
-Complex system if not integrated within EHR
-Requires minimal training
-Responsive/flexible customer service
ClinCalc-Web-based platform for vancomycin calculations
-Multiple patient specific and empiric dosing options
-Bayesian and two-level calculations
-Excellent for empiric kinetics
-Not adaptive with subsequent levels
Trough
AUC
Bayesian
Free-Multiple Bayesian models
-Editable Vd, ke, and patient parameters
-Straight-forward input
-Clear results
-Loading dose option
-Transparent description of calculations below results
TDMx Vancomycin-Web-based Bayesian calculator from Germany
-Allows for input of fixed dosing regimen or varying individual doses
-Beta-version
Trough
AUC
Bayesian
Free-Multiple Bayesian models
-Albumin, SCr, and TDM lab input as covariates
-Complex operability
-Requires solid understanding of vancomycin kinetics.
DoseMe-Rx-Web-based platform with option for integration into EHR
-Patient profiles can be saved
-Multiple adaptable Bayesian models available
Trough
AUC
Bayesian
Fee-based
Free 14-day trial available
-Allows for input of fixed dosing regimen or varying individual doses
-Iterative improvement
-Universal EHR integration
-24/7 technical support
-Multiple screens required for view of input and results
-Requires minimal training
BestDose-Software-based platform that requires installation, but not able to integrate with EHR
-Patient profiles can be saved
-Multiple adaptable Bayesian models available
Trough
AUC
Bayesian
Fee-based-Allows for input of fixed dosing regimen or varying individual doses
-Responsive to patient specific changes
-Challenging operability
-Requires extensive training
-Web-based application not available
PrecisePK-Software-based platform that requires installation, but not able to integrate with EHR
-Multiple adaptable Bayesian models available
Trough
AUC
Bayesian
Fee-based-Allows for input of fixed dosing regimen or varying individual doses
-Responsive to patient specific changes
-Requires some training
-Multiple screens required for view of input and results
-Lack of warning for poorly fit models
-Challenging operability
Global RPH-Web-based platform for vancomycin calculations-Offers copy-paste text template for EHR notesTrough
AUC
Free-Editable and varied kinetic parameters
-Complex empiric calculations
-Two-level AUC calculations
-Difficult to use if not familiar with empiric kinetics
-Extensive education related to dosing recommendations
-Lack of transparent description of calculations
-Complex input
Sanford Guide-Web-based platform
-Two-level calculations only
-Offers copy-paste text template for EHR notes
Trough
AUC (2-level)
Free, with subscription to Sanford Guide-No empiric AUC kinetic support
-First-order calculations
-Very simple and easy to use
Rxkinetics - Adult and Pediatric Kinetics (APK)-Software-based platform that requires installation, but not able to integrate with EHRTrough
AUC
Bayesian
Fee-based
Free 60-day trial available
-Unable to input varying prior doses (must input fixed dosing regimen)
-Unreliable accuracy w/2-level kinetics
-Limited technical support
-Requires training
MedCalc-Online free website for vancomycin calculations
-Last updated 2010
TroughFree-Only trough calculations based on single reference-Very simple operability
MPR-Web-based platform
-Currently unavailable
TroughFree but if use >5 times/month, need login-Trough only-Functionality requires Flash integration

 

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